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With more than 113 cannabinoids produced by the hemp plant, understanding the value and health benefits conveyed by individual cannabinoids can be confusing for consumers and wellness professionals alike. 

In 1964, Dr. Raphael Mechoulam and his team of researchers at Hebrew University in Jerusalem first isolated the tetrahydrocannabinol (THC) molecule from the cannabis plant. Mechoulam and his team have contributed decades of research to the study of cannabinoids such as cannabidiol (CBD) and their interaction with the mammalian endocannabinoid system (ECS). 

Research studies and anecdotal reports have indicated a wide range of medicinal benefits delivered by the cannabinoids found in cannabis. These include properties and mechanisms that deliver anti-inflammation and anti-cancer benefits. In addition, many cannabinoids have been found to support mood disorders by decreasing anxiety and depression and may be useful in the treatment of social anxiety and Post-Traumatic Stress Disorder

In addition, many cannabinoids have demonstrated neuroregenerative properties, meaning they can result in the preservation of existing brain cells or growth of new cells and neurotransmitters. This characteristic of several cannabinoids may help treat diseases such as Alzheimer disease and Parkinson’s disease. 

In recent years, it has been discovered that cannabinoids and terpenes can act synergistically. This has been termed the “entourage effect.” Dr. Ethan Russo supports this theory with his study “Cannabis Therapeutics and the Future of Neurology” by stating, “The inherent polypharmaceutical properties of cannabis botanicals offer distinct advantages over the current single-target pharmaceutical model and portend to revolutionize neurological treatment into a new reality of effective interventional and even preventative treatment.”

The following review is by no means a complete listing of cannabinoids. Rather, it is intended to familiarize readers with the most common wellness characteristics exhibited by some major and well-cited examples of this family of special herbal molecules—including examples of acidic precursors and varin varieties.


Cannabichromene (CBC)

CBC delivers no psychoactive effects, providing no risk of disorientation or disassociation. The medicinal benefits of CBC include promise as an anti-cancer agent, reductions in pain and inflammation and decreases in depression. CBC has also been shown to improve neuroplasticity, of potential value to those suffering dementia or special needs individuals with compromised neurology.

Cannabidiol (CBD)

CBD was first discovered in 1940, but the fact that it delivers medicinal efficacy failed to be understood until the 1960s. Today, patients and consumers are flocking to CBD and hemp-based products in the form of tinctures, topicals and other applications as an alternative to conventional—and sometimes ineffective—traditional therapies.

Cannabidiolic Acid (CBDA) 

CBDA, the acidic precursor to CBD, is a non-psychoactive cannabinoid that offers a wide range of medicinal benefits for patients and users. CBDA converts to CBD when heated or exposed to sunlight. 

Cannabidivarin (CBDV)

CBDV is the varin version of CBD. The molecule CBDV conveys many of the same medicinal efficacies of CBD, including anticonvulsant and anti-inflammatory properties and its ability to decrease or eliminate nausea. Like other cannabinoids, this molecule has been found to act as an analgesic and to be effective in the treatment of mood disorders, including social anxiety and depression. 

Cannabigerol (CBG)

CBG is sometimes referred to as the “mother of all cannabinoids” because its acidic precursor, CBGA, is responsible for producing the acidic precursors to CBC (CBCA), CBD (CBDA), and THC (THCA). 

Cannabinol (CBN)

CBN is a cannabinoid that is best known for delivering a reduction in anxiety and also acts as a sedative. CBN results from the degradation of THC whether from exposure to air (oxidation), light or mere age. It is believed that CBN could play a role in helping those suffering a variety of conditions, including insomnia, PTSD and social anxiety disorder. 

Tetrahydrocannabivarin (THCV)

THCV is the varin version of THC. It is most known for the fact that it is an appetite suppressant—meaning that it may provide value to those suffering obesity and type-2 diabetes. THCV may reduce anxiety and be a treatment in panic attacks and PTSD. 

Tetrahydrocannabinol (THC)

THC is the cannabinoid that comes to mind when people think of cannabis. It is the primary psychoactive molecule that makes us feel “high” or “stoned.” THC has been used by many for decades to relieve pain and inflammation, aid in sleep, increase appetite as well as reduce nausea and vomiting. More recently, THC has been found in scientific research to show promise as an anxiolytic and anticarcinogenic.


These statements have not been evaluated by the Food and Drug Administration for safety or efficacy. This product is not intended to diagnose, treat, cure or prevent any disease.